Season 10 of South Park starts in a week's time. It should be interesting to see how this goes since they've gotten in trouble over the Scientology episode and the Virgin Mary episode from the previous season. Will they tone the show down a bit?
Also, Isaac Hayes has left the show on bad terms so it's up in the air as to how they will address his absence on TV (he wasn't on a whole lot in recent seasons though).
Finally, what topics will they cover for the Current Event themed episodes? I was waiting during the whole Political Cartoons period for someone in the news to remember that South Park has also done an episode which depicts the Prophet Mohammed as one of Jesus' crime fighting pals from Super Best Friends. Would they bring his character back on air?