Finsihed it. Played as a soldier/shock trooper and did as many of the sidequests and planet exploring as I could before I tackled the main quest, so I was kind of overpowered for most of the main quest (finished up at level 49 I think). I spent most of the time partied with Ashley (backup fire support) and Tali (repairs and hacking, but I got her shotgun level fairly high for offense) and pretty much steamrolled everything. I didn't use Kaiden or Liara at all, and used Garrik and Wrex sparingly (although Wrex was actually a pretty good hybrid soldier/biotic). The plot was better than most movies Hollywood puts out, and the conclusion is satisfying while making the sequels obvious. I think it's planned on being a trilogy anyway. Plus, Bioware even threw in the inevitable romance angle that was OK, although Ashley's lines got a little painful when she started getting close to you. Plus, realistic buttcrack OMG!
All in all, I enjoyed it and might go back and play as a renegade so I can be a dick to everyone. Playing the nice guy sucks, I'd like to try waving my gun at everyone and hanging up on the asinine council when they get on my nerves.
EDIT: Forgot to add that those driving elements were about to drive me insane. Why did the designers feel the need to put everything on top of a mountain? A really STEEP mountain? I guess to increase the challenge, but it just irritated the shit out of me.