My Internet Explorer Homepage Is Locked

[The Electrifyer 0]

I've got a wierd problem on my internet explorer. When I go to the Internet Options in Internet Explorer, my home page is locked. The box where it has the homepage address written, along with the three buttons below it are all grey and un-clickable. I have no clue how this error came about and already ran Ad-Aware to remove any spyware. Does anyone know what else I can do to fix this??