It's come to my realization that GOB, or rather Will Arnett, can take perfectly mundane lines and make them hilarious. When Lindsey comes up with the scheme to open a bead shop and he starts out of the couch and shouts 'BEES?!' it always makes me crack up.
'Oh, great, guess it's time to jump on top of Kitty again! Everytime this family gets in trouble it's "Oh, let's have GOB fuck his way out of it!"
If you have the DVDs, check out the commentary. There's lots of funny stuff, especially the actors pointing out when they're cracking up in the background (particularly noticeable when Tobias walks into breakfast nude and GOB gives his 'big bear' eulogy). You can tell they have a wonderful time making this show. Wish I had a Nielson box, as it's the only thing I watch (at least until the FX shows come on again.)