Looking at it now, Vancouver doesn't have the goaltending to make it in the playoffs, as has been proven in the last two years. Colorado has a thin defense, but is capable of busting out a huge trade to change that. Detroit has the most depth, but are small up front with Zetterberg and Datsyuk being their big point guys.
Of those three teams, Detroit would make the finals, where Ottawa's speed and depth up front would be a big factor. Also, Hasek hasn't been the same this year, and I don't think that they trust CuJo in net. Ottawa has faith in Lalime, so they have that advantage.
I think Ottawa/Detroit is the best matchup, and can go 6 or 7 good, thrilling games, which is what the sport needs the most right now.