Mr. Show
(Or, to be totally proper, Mr. Show with Bob and David [although Bob and David themselves always wanted just "Mr. Show"]
You guys are making this too easy. The greatest sketch comedy show ever, four seasons of brilliance. Not a weak link in the cast, including many underappreciated players such as John Ennis, Tom Kenney, Jay Johnston and Paul F. Tompkins.
Sharp as a fucking tack, and able to be smartly stupid as well as outright brilliant.
David Cross is one of my comedic heroes.