Chargers have beaten the Colts just about every damned time (except for one game in like 2004 or 2005, a game the Chargers had won until a few errors in the end of the game pushed the Colts past them). But there's "NO" reason they shouldn't beat the piss out of the Chargers, right? The Chargers only win because of Gates, right? Not that speedy defense that magically appear in front of Manning passes, pickin' em off, right? Not those speedy blitzing linebackers to harass Manning, right? Yep, forget all about that and let's just foolishly pick Indianapolis just so I can nut in my shorts over Colts vs Pats Part 432498732498374.
This is not to say the Colts will lose to Chargers (I do believe the Colts win here), but to say there is no reason the Colts shouldn't treat the Chargers like some scrub team like Miami is just really fucking stupid.