It depends on what season Buffy you were talking about.
Season 2 Buffy would loose, but season 7 Buffy would win.
How so? Blade could just blow her away or use martial arts to smack her around and cut her down with his sword.
Blade is just a vampire and Buffy is the slayer. Slayers are stronger than vampires and Buffy is the greatest slayer there ever was.
Blade would loose, but I am just biased.
Yeah probably. Seems how Blade is a Vampire Hunter.
Blade is a vampire hunter, and Buffy is the slayer. Blade is a vampire and like I said before, slayers are more powerful than vampires.