you know, i never really ranked Vulture very high in the Spidey villian hierarchy...I'm almost positive we'd see a Venom storyline before we saw a Vulture storyline...I really don't see him being more than a secondary villian or at least on a tag team with another secondary villian...
now that I think about, Spidey really did have some subpar villians to deal with in the grand scheme of things in the Marvel Universe...Venom, Carnage, the Goblins and Octopus are the only ones that I'd call major league...and even they aren't on Doctor Doom, Red Skull, Magneto, Apocalypse, Thanos, etc. levels...