Oh man, I hope this is true, but I won't expect it. With 70,000 people present (ie, a much bigger than normal Mania crowd), I would think it would be tougher to have a crowd turn against a storyline (ie, cheer for the heel), only because the percentage of # of people attending likely goes up in the categories of children + women, who usually cheer the babyface/heels and are less likely to "try and make a statement". Chicago (last year) and NYC (WM XX) were easier venues to have something like this happen b/c of the rabid/vocal fanbase in these cities and that they are smaller venues than Detroit's, in my opinion.
The Skydome destroyed what should have been an epic NWO run and gave us "tonight, we're gonna see Stone Cold and Bradshaw take on the NWO!" for what felt just short of a full eon.
Then again, we also got Kevin Nash's "I'm going, bye."