I think Big Show is out to get surgery. I'm pretty sure we'll see Two Cool vs. Dudleys for the tag titles. In a wild guess, I see the card as maybe something like this:
Eddie vs. Bradshaw
Taker vs. Vince
Booker vs. RVD (some sort of gimmick, maybe)
Cena vs. Frenchy (US title)
2 Cool vs. Dudleys (tag titles)
Chavo vs. Nunzio vs. Rey (cruiserweight title)
And then they'll fill out the card with Haas, Rico, Holly, whoever.
Doesn't look too exciting. People are already predicting this to get one of the lowest buyrates ever...